Pubblicato uno studio sulla mastocitosi pediatrica

Riportiamo l’abstract di uno studio appena pubblicato dal gruppo francese che sta studiando la mastocitosi: hanno analizzato oltre 1700 casi di mastocitosi infantile, dei quali nel 67% si è avuta una regressione.

Complimenti per lo studio e … per la buona notizia.

Br J Dermatol. 2015 Feb 8. doi: 10.1111/bjd.13567.
Paediatric mastocytosis: a systematic review of 1747 cases.
Méni C1, Bruneau J, Georgin-Lavialle S, Le Saché de Peufeilhoux L, Damaj G, Hadj-Rabia S, Fraitag S, Dubreuil P, Hermine O, Bodemer C.
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Abstract
Paediatric mastocytosis was previously considered to be a benign and spontaneously regressing disease. However, this evolution is impossible to predict. To clarify the characteristics and course of paediatric mastocytosis, we performed a literature review of 1747 cases published between 1950 and April 2014. Lesions occurred before the age of 2 years in 90% of cases, and presented as urticaria pigmentosa (75% of cases), mastocytoma (20%) or diffuse cutaneous mastocytosis (5%). The male-to-female ratio was 1·4. KIT D816V mutation was detected in 34% of 215 tested patients. Clinical regression (complete or partial) occurred in 67% of cases and stabilization in 27%. However, the outcome was fatal in 2·9% of patients.
© 2015 British Association of Dermatologists.